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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Fig. 6

SOX2OT knockdown attenuated changes in neuronal marker levels in the hippocampus of mice with sepsis-associated encephalopathy. a Representative images showing protein bands of Ki67, DCX, Nestin, BLBP, and GFAP from CLP mice injected with SOX2OT siRNA or scrambled control. Densitometry-based protein quantitation of b Ki67, c DCX, d Nestin, e BLBP, and f GFAP. β-actin was used as an internal control (n = 8/group). *p < 0.05; **p < 0.01. Abbreviations: CLP, cecal ligation and perforation; si-CRTL; scrambled control siRNA; si-SOX2OT, SOX2OT siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094