Fig. 7

The effects of FPS-ZM1 treatment on lesion area and neuronal survival after SCI. a Dashed lines indicate the lesion border defined by GFAP immunoreactivity in saline- or FPS-ZM1-treated rats at 21 dpi. Scale bar = 500 μm. b Quantification of lesion area. N = 6/group, *P < 0.05. c A representative Nissl-stained section of saline- or FPS-ZM1-treated rats at 21 dpi. Broken lines mark the lesion borders. Arrows indicate Nissl-stained neurons. Scale bar = 600 μm in the left lower-magnification pictures and 100 μm in the right higher-magnification pictures from the boxes of left. d Quantification of the numbers of Nissl-stained neurons at 21 dpi. Note that the numbers of Nissl-stained neurons was significantly increased by FPS-ZM1 treatment in rostral and caudal areas of 600 μm adjacent to lesion. N = 6/group, **P < 0.01