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Table 1 Clinical characteristics of patients with and without post-stroke cognitive impairment

From: Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

Characteristics Mean (SD)
Without PSCI (n = 38) With PSCI (n = 25) P value
Age, year 61.1 (7.1) 68.4 (9.4) < 0.01
Education, year 10.4 (3.1) 7.5 (4.6) < 0.01
Male, No. (%) 31 (82) 16 (64) 0.12
APOE ε4 carrier, No. (%) 4 (11) 3 (12) 1.00a
Days between stroke onset and cognition evaluation 102.4 (29.7) 101.6 (21.0) 0.91
Days between stroke onset and 18F-THK-5351 scanning 92.8 (14.8) 104.4 (24.4) 0.04
Days between stroke onset and 18F-florbetapir scanning 100.4 (31.6) 101.2 (28.4) 0.92
Common vascular risk factors
 Hypertension, No. (%) 31 (82) 24 (96) 0.13a
 Diabetes mellitus, No. (%) 14 (37) 6 (24) 0.28
 Dyslipidemia, No. (%) 32 (84) 17 (68) 0.13
 Gout, No. (%) 7 (18) 3 (12) 0.72a
 PVL score 0.4 (0.8) 0.8 (1.1) 0.13
 DWML score 2.6 (1.3) 3.2 (1.2) 0.08
 Enlarged perivascular space, No. (%) 11 (29) 8 (32) 0.80
 Lobar microbleed, No. (%) 6 (16) 6 (24) 0.52a
 Deep microbleed, No. (%) 6 (16) 2 (8) 0.46a
 Lacune, No. (%) 10 (26) 4 (16) 0.34
Stroke features
 NIHSS 1.5 (1.3) 2.4 (2.3) 0.06
 Ischemic stroke, No. (%) 35 (92) 23 (92) 1.00a
 Left hemisphere stroke, No. (%) 17 (45) 15 (60) 0.24
 Supratentorial stroke lesion, No. (%) 35 (92) 23 (92) 1.00a
 Stroke volume, % 3.39E-6 (4.45E-6) 6.18E-6 (6.57E-6) 0.07
MTA score 0.8 (1.0) 1.3 (1.3) 0.09
Cortical thickness, mm 2.44 (0.08) 2.37 (0.10) 0.01
Total Z-SUM score at different Z levels
 Total Z-SUM-2, Z > 2 86763 (96363) 136773 (126302) 0.09
 Total Z-SUM-3, Z > 3 43536 (58763) 82344 (82885) 0.03
 Total Z-SUM-4, Z > 4 25822 (40406) 50558 (53591) 0.04
 Total Z-SUM-5, Z > 5 17404 (31432) 31059 (34631) 0.11
  1. APOE ε4 apolipoprotein E ε4, DWML deep white matter leukoaraiosis, MTA medial temporal atrophy, NIHSS National Institutes of Health Stroke Scale, PSCI post-stroke cognitive impairment, PVL periventricular leukoaraiosis, Z-SUM sum of 18F-THK-5351 uptake intensity Z scores
  2. Unless otherwise indicated, data are expressed as mean (SD)
  3. aAnalyzed by Fisher’s exact test