Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

Huang, Kuo-Lun; Hsiao, Ing-Tsung; Ho, Meng-Yang; Hsu, Jung-Lung; Chang, Yeu-Jhy; Chang, Ting-Yu; Liu, Chi-Hung; Chang, Chien-Hung; Wu, Yi-Ming; Wu, Kuan-Yi; Wey, Shiaw-Pyng; Yen, Tzu-Chen; Okamura, Nobuyuki; Lee, Tsong-Hai; Lin, Kun-Ju

doi:10.1186/s12974-020-01985-0

Journal of Neuroinflammation

Table 2 Factors associated with cognitive performance

From: Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

	¹⁸F-THK-5351 uptake intensity				Demographic factors		Vascular factors				Neurodegenerative factors
	Total Z-SUM-2	Total Z-SUM-3	Total Z-SUM-4	Total Z-SUM-5	Age, year	Education, year	NIHSS	Stroke volume, %	PVL score	DWML score	MTA score	Cortical thickness, mm
MoCA	− 0.26*	− 0.29*	− 0.28*	− 0.22	− 0.42***	0.59***	− 0.55***†	− 0.23†	− 0.23	− 0.32*†	− 0.11	0.55***†
NPI	0.21	0.21	0.21	0.17	0.08	− 0.16	0.58***†	0.28*†	0.06	0.19	− 0.10	− 0.32†
Depressive symptoms^a	0.07	0.05	0.04	0.01	0.06	− 0.11	0.62***†	0.19	0.25	0.22	− 0.06	− 0.24
Anxiety^b	− 0.10	− 0.13	− 0.13	− 0.13	0.12	− 0.31*	0.28*	− 0.10	0.13	− 0.03	0.13	− 0.20
IADL	0.37**†	0.41***†	0.39**†	0.31*†	0.31*	− 0.47***	0.58***†	0.29*†	0.12	0.19	0.03	− 0.44***
IQCODE^c	0.42***†	0.42***†	0.37**†	0.29*†	0.34**	− 0.25	0.42***†	0.4**†	0.24	0.43***†	0.19	− 0.35**
CDR-SOB	0.31*	0.36**†	0.35**†	0.27*†	0.35**	− 0.32**	0.57***†	0.29*†	0.18	0.23	0.03	− 0.45***†
Composite cognitive z score
General cognitive function	− 0.28*	− 0.36**†	− 0.38**†	− 0.34**†	− 0.26*	0.51***	− 0.43***†	− 0.31*†	− 0.24	− 0.29*†	− 0.15	0.39**
Memory function	− 0.11	− 0.16	− 0.18	− 0.15	− 0.35**	0.36**	− 0.37**†	− 0.14	− 0.38**†	− 0.27*	− 0.18	0.36**
Visuospatial function	− 0.28*	− 0.28*	− 0.27*	− 0.23	− 0.30*	0.21	− 0.25	− 0.24†	− 0.09	− 0.26*	0.12†	0.26*
Executive function	− 0.34**†	− 0.44***†	− 0.45***†	− 0.43***†	− 0.09	0.39**	− 0.41***†	− 0.36**†	− 0.06	− 0.21	− 0.10	0.32**
Language function	− 0.23	− 0.29*†	− 0.32*†	− 0.31*†	− 0.12	0.66***	− 0.25	− 0.28*†	− 0.09	− 0.22†	− 0.14	0.24

CDR clinical dementia rating, DWML deep white matter leukoaraiosis, IADL instrumental activities of daily living, IQCODE informant questionnaire on cognitive decline in the elderly, MoCA Montreal cognitive assessment, MTA medial temporal atrophy, NIHSS National Institutes of Health Stroke Scale, NPI neuropsychiatric inventory, PVL periventricular leukoaraiosis, SOB sum of boxes, Z-SUM sum of ¹⁸F-THK-5351 uptake intensity Z scores
*P < 0.05; **P < 0.01; ***P < 0.001; †P < 0.05 after adjustment for age and education
^aEvaluated by the NPI depression item 4
^bEvaluated by the NPI anxiety item 5
^CPerformed around 3 months after stroke

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ISSN: 1742-2094

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