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Table 3 Correlations of Z-SUM scores of the stroke core and perilesional regions with stroke severity, stroke volume, and cognitive performance

From: Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

  Stroke core regions   Perilesional regions
Z-SUM-2 Z-SUM-3 Z-SUM-4 Z-SUM-5 Z-SUM-2 Z-SUM-3 Z-SUM-4 Z-SUM-5
NIHSS 0.18 0.17 0.14 0.10 0.22 0.24 0.19 0.14
Stroke volume, % 0.73***† 0.69***† 0.63***† 0.56***† 0.41***† 0.51***† 0.55***† 0.54***†
MoCA − 0.13 − 0.12 − 0.09 − 0.05 − 0.26* − 0.29* − 0.29* − 0.24
NPI 0.14 0.12 0.09 0.05 0.20 0.21 0.22 0.19
Depressive symptomsa 0.05 0.04 0.00 − 0.04 0.07 0.05 0.04 0.02
Anxietyb − 0.10 − 0.10 − 0.10 − 0.10 − 0.09 − 0.13 − 0.13 − 0.13
IADL 0.19 0.18 0.15 0.12 0.37**† 0.41***† 0.41**† 0.33**†
IQCODEc 0.14 0.11 0.07 0.02 0.42***† 0.44***† 0.40**† 0.33**†
CDR-SOB 0.15 0.13 0.11 0.08 0.31* 0.37**† 0.37**† 0.29*†
Composite cognitive z score
 General cognitive function − 0.26* − 0.25* − 0.23 − 0.21 − 0.27* − 0.35**† − 0.38**† − 0.35**†
 Memory function − 0.12 − 0.11 − 0.10 − 0.09 − 0.11 − 0.16 − 0.18 − 0.15
 Visuospatial function − 0.18 − 0.18 − 0.17 − 0.16 − 0.28* − 0.28* − 0.27* − 0.23
 Executive function − 0.28* − 0.27* − 0.25 − 0.21 − 0.33**† − 0.43***† − 0.46***† − 0.44***†
 Language function − 0.31* − 0.31* − 0.30* − 0.27* − 0.22 − 0.28*† − 0.31*† − 0.30*†
  1. CDR clinical dementia rating, IADL instrumental activities of daily living, IQCODE informant questionnaire on cognitive decline in the elderly, MoCA Montreal cognitive assessment, NIHSS National Institutes of Health Stroke Scale, NPI neuropsychiatric inventory, SOB sum of boxes, Z-SUM sum of 18F-THK-5351 uptake intensity Z scores
  2. *P < 0.05; **P < 0.01; ***P < 0.001; †P < 0.05 after adjustment for age and education
  3. aEvaluated by the NPI depression item 4
  4. bEvaluated by the NPI anxiety item 5
  5. cPerformed around 3 months after stroke