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Table 4 Correlations of Z-SUM scores with cognitive performance in patients with left and right hemisphere stroke

From: Investigation of reactive astrogliosis effect on post-stroke cognitive impairment

  MoCA IADL IQCODEa CDR-SOB General cognitive function Memory Visuospatial function Executive function Language
Patients with left hemisphere stroke (n = 30)
 Stroke volume,% − 0.24 0.25 0.33 0.13 − 0.36† − 0.15 − 0.19 − 0.34 − 0.56*
 Total Z-SUM-2 − 0.41* 0.46* 0.40* 0.45*† − 0.48*† − 0.38* − 0.41*† − 0.40* − 0.42*
 Total Z-SUM-3 − 0.44*† 0.48*† 0.34 0.49*† − 0.54*† − 0.39*† − 0.36† − 0.49*† − 0.51*†
 Total Z-SUM-4 − 0.41*† 0.41* 0.24 0.46*† − 0.52*† − 0.36† − 0.30† − 0.48*† − 0.52*†
 Total Z-SUM-5 − 0.32† 0.32 0.16 0.36*† − 0.44*† − 0.29† − 0.20 − 0.43*† − 0.48*†
 Ipsilateral Z-SUM-2 − 0.57*† 0.55*† 0.41*† 0.55*† − 0.57*† − 0.42*† − 0.46*† − 0.50† − 0.52†
 Ipsilateral Z-SUM-3 − 0.56*† 0.54*† 0.34 0.55*† − 0.59*† − 0.40*† − 0.40*† − 0.55*† − 0.56*†
 Ipsilateral Z-SUM-4 − 0.51*† 0.47*† 0.25 0.50*† − 0.55*† − 0.36† − 0.32† − 0.53*† − 0.56*†
 Ipsilateral Z-SUM-5 − 0.40*† 0.37*† 0.15 0.39*† − 0.47*† − 0.28† − 0.22† − 0.47*† − 0.52*†
Patients with Right Hemisphere Stroke (n= 28)
 Stroke volume, % − 0.27 0.30 0.43*† 0.41*† − 0.33† − 0.20 − 0.37 − 0.44*† 0.01
 Total Z-SUM-2 − 0.14 0.23 0.39* 0.20 − 0.09 0.08 − 0.17 − 0.27 − 0.05
 Total Z-SUM-3 − 0.15 0.29 0.45* 0.25 − 0.19 0.01 − 0.20 − 0.38*† − 0.07
 Total Z-SUM-4 − 0.13 0.32 0.46* 0.26 − 0.22 − 0.01 − 0.24 − 0.42*† − 0.08
 Total Z-SUM-5 − 0.07 0.26 0.38* 0.18 − 0.21 0.00 − 0.28 − 0.41*† − 0.07
 Ipsilateral Z-SUM-2 − 0.16 0.28 0.43* 0.19 − 0.16 0.06 − 0.25 − 0.37† − 0.08
 Ipsilateral Z-SUM-3 − 0.16 0.32 0.47* 0.24 − 0.22 0.00 − 0.25 − 0.44*† − 0.09
 Ipsilateral Z-SUM-4 − 0.13 0.33 0.46* 0.26 − 0.23 − 0.02 − 0.25 − 0.44*† − 0.08
 Ipsilateral Z-SUM-5 − 0.07 0.26 0.39* 0.18 − 0.21 0.00 − 0.28 − 0.41*† − 0.07
  1. CDR clinical dementia rating, IADL instrumental activities of daily living, IQCODE informant questionnaire on cognitive decline in the elderly, MoCA Montreal cognitive assessment, NIHSS National Institutes of Health Stroke Scale, NPI neuropsychiatric inventory, SOB sum of boxes, Z-SUM sum of 18F-THK-5351 uptake intensity Z scores
  2. *P < 0.05; † P < 0.05 after adjustment for age and education
  3. aPerformed around 3 months after stroke