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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

Fig. 2

Sestrin2 reduced cell apoptosis after tMCAO. ac Western blot and quantification analysis show the expression of bax, bcl2, and cleaved caspase3 in Sham, NS, and Sesn group at 3 days after tMCAO. C-cas3 = cleaved caspase3. N = 4–5 per group. Data are presented as mean ± SEM, *p < 0.05, NS vs. Sesn. d, e TUNEL staining and bar graph show the number of TUNEL+ (red) cells in NS and Sesn groups 1 day after tMCAO. White arrows point at TUNEL+/DAPI+ cells. Scale bar = 100 μm. N = 5 per group. Data are presented as mean ± SEM, *p < 0.05, NS vs. Sesn. f Representative photos of TUNEL+/Neun+ cells in NS and Sesn groups. White arrows point at TUNEL+/Neun+ cells. Scale bar = 50 μm

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