Fig. 1.
MRS5980 attenuates gross histopathological changes to cortical tissue following CCI TBI. a–f When compared to the intact brain structure of sham mice (a and higher magnification in b), tissue disorganization and inflammation increased in the penumbra area of the mouse brain sections 24 h after CCI TBI (TBI + Veh; c and higher magnification in d). These histopathological changes were attenuated in mice treated with MRS5980 (1 mg/kg, i.p.) after CCI TBI (e and higher magnification in f). g Histological scores of sagittal brain slices (three slices per animal). ND = not detectable; yellow box indicates region of higher magnification. Data are mean ± SEM of 10 mice/group and analyzed by Kruskal-Wallis [H(2)- = 24.17, p = 5.63 × 10−6] and Wilcoxon signed-rank test. *p < 0.05 vs. sham and †p < 0.05 vs. TBI + Veh