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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

Fig. 5

Minocycline application inhibited microglia reaction in optic nerves. a Staining of phagocytes (Iba1+, red), microglia (Tmem119+ and Iba1+, green), macrophages (Tmem119 and Iba1+), microglia/macrophages in an active state (ED1, red, arrows), and cell nuclei (DAPI, blue) was carried out. b The Iba1+ phagocyte number was increased in the S100B group compared to the naïve and the PBS group. Minocycline treatment reduced phagocyte proliferation. c In the S100B group, the number of microglia was increased compared to the naïve, the PBS, the 13.5 mg/kg mino, and the 25 mg/kg mino group. d Comparable phagocyte (Tmem119 and Iba1+) counts were seen in all groups. e An upregulation of active microglia/macrophages was observed in S100B optic nerves compared to all other groups. Scale bar: 20 μm, n = 6/group, **p < 0.01, ***p < 0.001 vs. naïve group, #p < 0.05, ##p < 0.01, ###p < 0.001 vs. PBS group, ¥p < 0.05, ¥¥p < 0.01; ¥¥¥p < 0.001 vs. S100B group

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