Table 2 Data of a- and b-wave amplitudes as well as PhNR recorded from naïve, PBS, S100B, 13.5 mg/kg mino, and 25 mg/kg mino animals. Values of light flash intensity (cd.s/m2) are displayed as mean ± SEM. p values < 0.05 are shown in bold
From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model
|  | Cd.s/m2 | Mean ± SEM [μV] | P-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  | Naïve | PBS | S100B | 13.5 mg/kg mino | 25 mg/kg mino | Naïve vs. PBS | Naïve vs. S100B | Naïve vs. 13.5 mg/kg mino | Naïve vs. 25 mg/kg mino | PBS vs. S100B | PBS vs. 13.5 mg/kg mino | PBS vs. 25 mg/kg mino | S100B vs. 13.5 mg/kg mino | S100B vs. 25 mg/kg mino | 13.5 vs. 25 mg/kg mino |
A-wave | 0.1 | 58.5 ± 5.6 | 42.3 ± 7.1 | 40.3 ± 6.2 | 85.7 ± 11.6 | 73.2 ± 10.1 | 0.66 | 0.56 | 0.19 | 0.74 | 1.00 | 0.01 | 0.10 | 0.001 | 0.07 | 0.83 |
0.3 | 80.6 ± 15.4 | 70.4 ± 8.1 | 68.8 ± 10.2 | 98.2 ± 9.8 | 81.7 ± 6.0 | 0.96 | 0.93 | 0.75 | 1.00 | 1.00 | 0.35 | 0.94 | 0.29 | 0.90 | 0.79 | |
1.0 | 112.1 ± 13.4 | 92.3 ± 6.5 | 74.5 ± 3.8 | 113.9 ± 16.2 | 95.5 ± 5.1 | 0.65 | 0.10 | 1.00 | 0.78 | 0.74 | 0.58 | 1.00 | 0.08 | 0.60 | 0.71 | |
3.0 | 120.3 ± 12.2 | 114.0 ± 5.6 | 85.0 ± 7.0 | 126.5 ± 17.5 | 102.7 ± 3.8 | 0.99 | 0.15 | 0.99 | 0.76 | 0.32 | 0.92 | 0.94 | 0.07 | 0.76 | 0.51 | |
10.0 | 150.3 ± 17.2 | 131.8 ± 6.2 | 101.7 ± 5.9 | 152.4 ± 15.4 | 136.7 ± 9.5 | 0.80 | 0.054 | 1.00 | 0.92 | 0.40 | 0.73 | 1.00 | 0.04 | 0.26 | 0.88 | |
25.0 | 157.1 ± 13.6 | 128.7 ± 8.0 | 105.7 ± 5.9 | 164.6 ± 20.4 | 134.7 ± 7.1 | 0.49 | 0.04 | 1.00 | 0.70 | 0.68 | 0.26 | 1.00 | 0.02 | 0.47 | 0.43 | |
B-wave | 0.1 | 223.8 ± 31.1 | 203.5 ± 15.4 | 179.7 ± 6.7 | 251.8 ± 22.4 | 246.1 ± 20.4 | 0.96 | 0.57 | 0.87 | 0.94 | 0.93 | 0.49 | 0.60 | 0.14 | 0.19 | 1.00 |
0.3 | 272.2 ± 24.9 | 238.0 ± 20.6 | 208.0 ± 8.2 | 305.0 ± 19.6 | 281.0 ± 23.6 | 0.76 | 0.20 | 0.78 | 1.00 | 0.83 | 0.17 | 0.57 | 0.02 | 0.11 | 0.92 | |
1.0 | 325.1 ± 36.9 | 272.2 ± 14.0 | 208.5 ± 12.7 | 323.7 ± 33.1 | 306.7 ± 12.3 | 0.55 | 0.02 | 1.00 | 0.98 | 0.37 | 0.57 | 0.85 | 0.02 | 0.06 | 0.99 | |
3.0 | 322.8 ± 30.0 | 275.1 ± 16.1 | 244.4 ± 14.2 | 324.8 ± 36.4 | 291.6 ± 13.3 | 0.63 | 0.17 | 1.00 | 0.89 | 0.89 | 0.59 | 0.99 | 0.16 | 0.63 | 0.86 | |
10.0 | 357.0 ± 46.2 | 300.4 ± 8.7 | 376.4 ± 13.0 | 360.7 ± 52.6 | 373.6 ± 17.4 | 0.74 | 0.44 | 1.00 | 1.00 | 0.99 | 0.70 | 0.53 | 0.39 | 0.26 | 1.00 | |
25.0 | 377.5 ± 47.6 | 337.2 ± 14.5 | 277.0 ± 14.7 | 327.1 ± 42.6 | 324.6 ± 8.7 | 0.88 | 0.16 | 0.76 | 0.73 | 0.63 | 1.00 | 1.00 | 0.77 | 0.80 | 1.00 | |
PhNR | 0.1 | − 24.2 ± 3.0 | − 22.2 ± 1.7 | − 11.7 ± 2.0 | − 18.1 ± 3.3 | − 20.8 ± 4.5 | 0.99 | 0.06 | 0.62 | 0.93 | 0.15 | 0.87 | 1.00 | 0.60 | 0.25 | 0.97 |