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Table 2 Data of a- and b-wave amplitudes as well as PhNR recorded from naïve, PBS, S100B, 13.5 mg/kg mino, and 25 mg/kg mino animals. Values of light flash intensity (cd.s/m2) are displayed as mean ± SEM. p values < 0.05 are shown in bold

From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

  Cd.s/m2 Mean ± SEM [μV] P-values
   Naïve PBS S100B 13.5 mg/kg mino 25 mg/kg mino Naïve vs. PBS Naïve vs. S100B Naïve vs. 13.5 mg/kg mino Naïve vs. 25 mg/kg mino PBS vs. S100B PBS vs. 13.5 mg/kg mino PBS vs. 25 mg/kg mino S100B vs. 13.5 mg/kg mino S100B vs. 25 mg/kg mino 13.5 vs. 25 mg/kg mino
A-wave 0.1 58.5 ± 5.6 42.3 ± 7.1 40.3 ± 6.2 85.7 ± 11.6 73.2 ± 10.1 0.66 0.56 0.19 0.74 1.00 0.01 0.10 0.001 0.07 0.83
0.3 80.6 ± 15.4 70.4 ± 8.1 68.8 ± 10.2 98.2 ± 9.8 81.7 ± 6.0 0.96 0.93 0.75 1.00 1.00 0.35 0.94 0.29 0.90 0.79
1.0 112.1 ± 13.4 92.3 ± 6.5 74.5 ± 3.8 113.9 ± 16.2 95.5 ± 5.1 0.65 0.10 1.00 0.78 0.74 0.58 1.00 0.08 0.60 0.71
3.0 120.3 ± 12.2 114.0 ± 5.6 85.0 ± 7.0 126.5 ± 17.5 102.7 ± 3.8 0.99 0.15 0.99 0.76 0.32 0.92 0.94 0.07 0.76 0.51
10.0 150.3 ± 17.2 131.8 ± 6.2 101.7 ± 5.9 152.4 ± 15.4 136.7 ± 9.5 0.80 0.054 1.00 0.92 0.40 0.73 1.00 0.04 0.26 0.88
25.0 157.1 ± 13.6 128.7 ± 8.0 105.7 ± 5.9 164.6 ± 20.4 134.7 ± 7.1 0.49 0.04 1.00 0.70 0.68 0.26 1.00 0.02 0.47 0.43
B-wave 0.1 223.8 ± 31.1 203.5 ± 15.4 179.7 ± 6.7 251.8 ± 22.4 246.1 ± 20.4 0.96 0.57 0.87 0.94 0.93 0.49 0.60 0.14 0.19 1.00
0.3 272.2 ± 24.9 238.0 ± 20.6 208.0 ± 8.2 305.0 ± 19.6 281.0 ± 23.6 0.76 0.20 0.78 1.00 0.83 0.17 0.57 0.02 0.11 0.92
1.0 325.1 ± 36.9 272.2 ± 14.0 208.5 ± 12.7 323.7 ± 33.1 306.7 ± 12.3 0.55 0.02 1.00 0.98 0.37 0.57 0.85 0.02 0.06 0.99
3.0 322.8 ± 30.0 275.1 ± 16.1 244.4 ± 14.2 324.8 ± 36.4 291.6 ± 13.3 0.63 0.17 1.00 0.89 0.89 0.59 0.99 0.16 0.63 0.86
10.0 357.0 ± 46.2 300.4 ± 8.7 376.4 ± 13.0 360.7 ± 52.6 373.6 ± 17.4 0.74 0.44 1.00 1.00 0.99 0.70 0.53 0.39 0.26 1.00
25.0 377.5 ± 47.6 337.2 ± 14.5 277.0 ± 14.7 327.1 ± 42.6 324.6 ± 8.7 0.88 0.16 0.76 0.73 0.63 1.00 1.00 0.77 0.80 1.00
PhNR 0.1 − 24.2 ± 3.0 − 22.2 ± 1.7 − 11.7 ± 2.0 − 18.1 ± 3.3 − 20.8 ± 4.5 0.99 0.06 0.62 0.93 0.15 0.87 1.00 0.60 0.25 0.97