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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

Fig. 3

Surgery up-regulates CXCL13 in mouse hippocampus. a Relative level of CXCL13 mRNA was measured by RT-qPCR in wild type mice at 1, 3, and 7 days after surgery. b Western blotting analysis of CXCL13 at 7 days after surgery. β-actin was used as an internal control (n = 8 per group). c Representative images of CXCL13 immunohistochemistry in the hippocampal CA1, CA3, and dentate gyrus regions. Positively stained cells are brown (red arrow). Magnification, × 5 for total hippocampus; × 20 for regions CA1, CA3, and DG in hippocampus. All experiments were performed with n = 4 per group. *P < 0.05 vs. control. CXCL13 C-X-C motif chemokine 13, DG dentate gyrus, RT-qPCR reverse transcription-quantitative polymerase chain reaction

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Journal of Neuroinflammation

ISSN: 1742-2094