Fig. 4

NOD1 inhibition significantly reduced the inflammatory response in response to ICH. Levels of iNOS, TNF-α, and IL-1β protein a, c in the brain in the indicated groups (n = 3 mice for each group; *P < 0.01 vs. the sham group, #P < 0.01 vs. the ICH/ICH + DMSO group) and b, d in the primary microglia from the indicated groups (n = 3 experiments for each group; *P < 0.01 vs. the ctrl group, #P < 0.01 vs. the Hemin group); RIP2, total and phosphorylated JNK/P38 MAPK, and IκBα protein levels e, g in the brain in the indicated groups (n = 3 mice for each group; *P < 0.01 vs. the sham group, #P < 0.01 vs. the ICH/ICH + DMSO) and f, h in the primary microglia from the indicated groups (n = 3 experiments for each group; *P < 0.01 vs. the ctrl group, #P < 0.01 vs. the hemin group). All data are representative of three independent experiments