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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK

Fig. 3

Effect of SIS3 and LPS on IBA-1 and GFAP expression in rats. a Representative figures of microglia and astrocyte (immunohistochemistry of IBA-1 and GFAP) in the SN and striatum. Scale bar = 100 μm in the upper panels of a, b, and c; 50 μm in the below panels of a, b, and c. d Quantification of IBA-1+ cell number in the SN is shown. e Quantification of IBA-1+ cell number in the striatum is shown. f Quantification of GFAP+ cell number in the SN is shown. Results are expressed as mean ± SEM. N = 6. #p < 0.01, compared with the rats treated with vehicle; ▼p < 0.01, compared with the rats treated with vehicle, SIS3, or LPS. LPS, lipopolysaccharide (1 mg/kg); SIS3 (4 μg/each side)

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Journal of Neuroinflammation

ISSN: 1742-2094