Fig. 2
Inflammatory and microglia/macrophage mRNA expression profile in the ipsilateral hemisphere 1 day after pMCAO. (a-l) Quantification of Il6, Nos2, Il1b, Fcgr3, Fcgr2b, Mrc1, Arg1, Ym1, Tgfb1 and Trem2 by qRT-PCR in the ipsilateral hemisphere 1 day after pMCAO. Following pMCAO, the expression of (a) Il6, (b) Nos2, (c) Il1b, (f) Mrc1 and (h) Ym1 was higher, and (g) Arg1 showed an upward trend, if compared to the sham vehicle group. Treatment with MS-275 and resveratrol promoted a mild reduction of the expression of (a) Il6, (f) Mrc1 and (g) Arg1, and prevented the increase of (b) Nos2, (c) Il1b and (h) Ym1 transcript levels. One-way ANOVA followed by Holm-Å Ãdák test, °trend, *p<0.05, **p<0.01 vs. sham vehicle; #trend, §§p<0.001 vs. MCAO vehicle. Data (means ± s.e.m., n = 6) are expressed as fold changes over values obtained in ipsilateral hemisphere from sham operated mice.