Fig. 3

ChIP analysis of RelA binding and histone H3 acetylation (K9/18) at Nos2 and Il6 promoters. ChIP analysis of RelA binding and histone H3 acetylation (K9/18) at the (a, b) Nos2 and (c, d) Il6 promoters. Treatment with MS-275 and resveratrol reduced the pMCAO-induced increase in both (a) RelA binding and (b) the acetylation of H3 histone at the Nos2 promoter. Permanent MCAO did not increase (c) RelA binding and (d) the acetylation of H3 histone at the Il6 promoter. Data (means ± s.e.m., n = 3) are expressed as fold changes over values obtained in ipsilateral hemisphere from sham operated mice (dashed line). t-test, *p<0.05 versus pMCAO-vehicle.