Table 2 Fold regulation of gene expression in CCL3^−/−mice compared to wild-type mice at day 7 or 21 after SCI

B2m (Beta 2 microglobulin)

− 2.97

0.046

Component of MHC class I molecule [46]

Bmp7 (Bone morphogenetic protein 7)

− 3.24

0.036

Anti-inflammatory protein, neuroprotective function [47, 48]

CCl4 (CCL4)

− 5.27

0.009

CCR1 agonist, role in wound repair and inflammation [49]

Ccl11 (CCL11, eotaxin-1)

− 5.98

0.021

Eosinophil chemotactic protein [50]

CCl12 (CCL12)

− 4.39

0.035

Pro-inflammatory cytokine [51]

Cd70 (CD70)

− 3.52

0.009

Pro-inflammatory, promoting T cell responses [52]

Cx3cl1 (CX3CL1, Fractalkine)

− 5.36

0.003

Chemotactic cytokine [53]

Ifna2 (IFNα2)

− 5.3

0.003

Pro-inflammatory cytokine with role in anti-tumor immunity [54]

Il12b (IL12p40)

− 4.90

0.008

Pro-inflammatory cytokine [55]

Il16 (IL16)

− 9.67

0.049

Chemoattractant for lymphocytes and macrophages [56]

Il17f (IL17F)

− 5.24

0.001

Pro-inflammatory cytokine [57]

Il1a (IL1α)

− 2.25

0.002

Pro-inflammatory cytokine [58]

Il1rn (IL1 receptor antagonist)

− 13.93

0.015

Anti-inflammatory protein [59]

Il27 (IL27)

− 3.16

0.019

Anti-inflammatory protein [60]

Mif (Macrophage migration inhibitory factor)

− 2.54

0.005

Pro-inflammatory cytokine [61]

Osm (Oncostatin M)

− 8.96

0.041

Protein with role in inflammation, hematopoiesis [62]

Thpo (Thrombopoietin)

− 19.65

0.008

Megakaryocyte growth and development factor [63]

Tnf (TNF)

− 3.85

0.034

Pro-inflammatory cytokine [64]

Bmp6 (Bone morphogenetic protein 6)

− 2.32

0.034

Iron metabolism [65]

Ifng (IFNγ)

− 4.2

0.031

Pro-inflammatory cytokine [66]

Pf4 (Platelet factor 4/CXCL4)

− 2.76

0.008

Pro-inflammatory chemokine [67]

Thpo (Thrombopoietin)

− 2.89

0.036

Megakaryocyte growth and development factor [63]

Tnfrsf11b (Osteoprotegerin)

− 14.42

0.031

Inhibitor of osteoclast function [68]