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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model

Fig. 6

Chronic noise exposure diminishes tight junction protein expression in the intestine and hippocampus of WT and APP/PS1 mice. a–d Protein expression levels of the main tight junction components in intestine samples (n = 5). e–h Protein expression levels of main tight junction proteins in the hippocampus (n = 5). GAPDH was used as a loading control. Data are presented as the mean ± standard deviation. *P < 0.05, **P < 0.01 vs. WT CON group; #P < 0.05, ##P < 0.01 vs. APP/PS1 CON group. §, exposure effect, P < 0.05; ¶, genotype effect, P < 0.05; ǂ, interaction effect, P < 0.05. CON, control groups; NOISE, noise-exposed groups; WT, wild-type mice; APP/PS1, APP/PS1 transgenic mice. i–l Morphology of the ultrastructural changes in tight junctions under transmission electron microscopy (magnification × 6000). i Wild-type, control groups. j APP/PS1 transgenic mice. k Wild-type, noise-exposed group. l APP/PS1 transgenic mice, noise-exposed group

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Journal of Neuroinflammation

ISSN: 1742-2094