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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein

Fig. 6

Anti-miR-142 enhanced dendritic spine development in rat hippocampal neurons exposed to the SPS procedure. a MiR-142 relative expression in primary hippocampal neurons 2 days after transfection of LV-anti-miR-142 by RT-qPCR. b Representative image indicating F-action and β-tubulin Ш immunopositive cells in the CM, L-CM, sh-miR-NC, and sh-miR groups. c Graphic representation of the number of dendritic spines in the CM, L-CM, sh-miR-NC, and sh-miR groups. d Four types (mushroom, stubby, thin, and filopodia) dendritic spines in hippocampal neurons. e Fraction of mushroom, stubby and thin, filopodia spines from primary hippocampal neurons in the CM, L-CM, sh-miR-NC, and sh-miR groups. One-way ANOVA followed by Bonferroni’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094