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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis

Fig. 5

Endometriosis upregulated neuronal MyD88 in the dorsal root ganglion. a Western blot analyzed the time course of Myd88 expression in the DRG from naïve, sham, 3 days, 7 days, 14 days, and 21 days after surgery. b For the expression levels of Myd88, there was no significant difference between naïve, sham, and 3 days after surgery. On postoperative day 7, 14, and 21 group, Myd88 was upregulated in the DRG. N = 4, one-way ANOVA, *p < 0.05, versus naive and sham. ch Immunofluorescence showed neuronal distribution of Myd88 in rat DRGs of sham and EM 14 days groups. Scale bar 50 μm. i Myd88 was expressed in the large-, medium-, and small-sized neurons in the dorsal root ganglion. Immunofluorescence staining showed a significantly higher percentage of Myd88-immunopositive cells in small-sized DRG neurons in EM 14d rats compared with that in sham rats. n > 100 neurons from 3 rats in each group, *p < 0.05, EM 14d vs sham, chi-square test

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