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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Fig. 3

Intestinal inflammation during chronic TBI induces and exacerbates impairments in fine motor coordination. DSS administration induced increases in foot faults in Sham- and TBI mice beginning during the DSS injury phase (PTD32) and persisting through the end of the fourth week of the recovery phase (PTD63) a–d. Foot faults at specific time points within the study; PTD35 b, PTD49 c, and PTD63 d. No persistent impairments are observed in Sham-injured mice not administered DSS (Sham) or in Naïve mice administered DSS (Naïve+DSS). Data expressed as mean ± s.e.m (n = 15–21/group). PTD 1-28: **** p < 0.0001 TBI vs Naïve/Sham, ++++ p < 0.0001 TBI + DSS vs Naïve+DSS/Sham+DSS; PTD 32-63: **** p < 0.0001 TBI vs Naïve/Sham, ^^ p < 0.01 vs Naïve+DSS, ^^^ p < 0.001 vs Naïve+DSS, ^^^^ p < 0.0001 vs Naïve+DSS, + p < 0.05 vs Sham or TBI, ++ p < 0.01 vs Sham or TBI, +++ p < 0.001 vs Sham or TBI, ++++ p < 0.0001 vs Sham or TBI, ## p < 0.01 vs Sham+DSS, ### p < 0.001 vs Sham+DSS, #### p < 0.0001 vs Sham+DSS

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Journal of Neuroinflammation

ISSN: 1742-2094