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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

Fig. 1

Effect of poly(I:C) pre-treatment on Escherichia coli meningitis in a neutropenic and b immunocompetent mice. a Survival time of neutropenic mice was significantly increased after pre-treatment with poly(I:C) at a dose of 200 μg compared to the vehicle group (P = 0.0016, log-rank test). Survival was 75% (15/20) when pre-treated with poly(I:C) 200 μg versus 25% (5/20) when receiving vehicle (P = 0.0038, Fisher’s exact test). Median survival time was similar in vehicle-treated mice (60 h) and in animals pre-treated with poly(I:C) 20 μg (54 h) (P = 0.71, log-rank test). b Survival time after infection was not significantly longer in wt mice pre-treated with poly(I:C) 200 μg (P = 0 .13, log-rank test). Survival 14 days after infection was 21.7% (5/23) in animals pre-treated with poly(I:C) 200 μg versus 13.6% (3/22) in the control group (P = 0.70, Fisher’s exact test)

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Journal of Neuroinflammation

ISSN: 1742-2094