Fig. 1

EMD mice display a significant reduction in HFD-induced obesity phenotype. Wt and EMD male mice were fed with NCD or HFD for 14 weeks. a Under NCD, bodyweight gain during 14-week feeding was significantly increased in EMD mice compared to wt. HFD administration significantly increased body weight in both mice groups but this increase was much more significant in wt group (n = 9, in all animal groups). b Fat weight in NCD-fed or HFD-fed mice at week 14. c Glucose tolerance test in wt and EMD mice fed with NCD or HFD for 14 weeks in the 16-h-fasted state (wt NCD, n = 5; wt HFD, n = 6; EMD NCD, n = 8; EMD HFD n = 9). d Scatter plots with bars represent the area under the glucose curve from the glucose tolerance test. e Insulin tolerance test in wt and EMD mice fed with NCD or HFD for 14 weeks in the 6-h-fasted state (wt NCD, n = 5; wt HFD, n = 6; EMD NCD, n = 8; EMD HFD n = 9). f Scatter plots with bars represent the area under the glucose curve from the insulin tolerance test. All data are presented as the mean ± SEM. Statistical significance in a, c and e is based on multivariate ANOVA analysis followed by Games-Howell post hoc test. Statistical significance in b, d, and f was based on one-way ANOVA followed by Games-Howell’s (b and d) or Tukey’s (f) post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001