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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception

Fig. 1

Biosynthetic pathways of arachidonic acid-mediated prostaglandins (PGs). PGH2 is generated from arachidonic acid by enzymatic reactions of COX-1 or COX-2, and is further metabolized into PGE2, PGD2, PGI2, or TXA2 by specific synthases. When dehydrated, PGE2 is converted into PGA2 and PGB2, and PGD2 is converted into PGJ2. PGJ2 can further be isomerized into 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2). TXA2 is rapidly hydrolyzed into TXB2

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Journal of Neuroinflammation

ISSN: 1742-2094