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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats

Fig. 8

Schematic shows the regulation of the NGF gene expression and the involvement of C/EBPα in chronic inflammatory pain. Chronic inflammation leads to upregulation of miR-29b expression level which represses the activity of DNMT3b, enhances the demethylation of the NGF gene promoter region, and promotes the binding of C/EBPα with NGF gene promoter, resulting in upregulation of NGF gene expression, and contribute to the maintenance of chronic inflammatory pain

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Journal of Neuroinflammation

ISSN: 1742-2094