Fig. 9

Quantitative analysis of the effect of letrozole, LPS, and tibolone on the phagocytosis of brain-derived cellular debris. Cy3 fluorescence intensity per cell in male and female astrocytes treated for 39 h with letrozole, tibolone, or control medium and 24 h with LPS and then incubated for 1 h with Cy3-conjugated brain-derived cellular debris. Data are presented as median ± ranges. Significant differences: ***p < 0.001 versus the control group of the same sex, ^%%%p < 0.001; ^%%p < 0.01 versus the LPS group of the same sex, ^$$$p < 0.001 versus the LPS+letrozole group of the same sex, ^@@@ p < 0.001 versus the LPS+tibolone group of the same sex, ^###p < 0.001, ^#p < 0.05 versus the same group of the other sex, being annotated in the group with higher median