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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway

Fig. 1

miR-29b-3p is downregulated in the cerebral cortex of MCAO rats. TTC staining (a) and the quantification (b) of the ischemic brain injury of MCAO rats. TUNEL staining (c) and the quantification (d) of the apoptosis in the cerebral cortex of MCAO rats (scale bar = 25 μm). e, f Western blot analysis of the expression of apoptosis- and angiogenesis-related proteins (Bcl-2, Bax, Cleaved caspase-3, VEGFA and VEGFR2) in the cerebral cortex. g, h CD31 immunofluorescence staining showed the microvessel density (MVD) in the cerebral cortex (scale bar = 25 μm). i RT-qPCR analysis of the expression of miR-29b-3p in the cerebral cortex of rats. *p < 0.05 vs. the sham group. The measurement data are expressed in the form of mean ± standard deviation. The comparison between the two groups was carried out by the independent sample t test. n = 7 rats in each group

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