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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

Fig. 6

Endotoxemia-elicited neurodegeneration is ameliorated in NLRP3−/− or IL-1R1−/− mice. Representative images of TH immunostaining (a) in SN of WT, NLRP3−/−, and IL-1R−/− mice at 10 months after LPS 5 mg/kg or saline i.p injection were shown (n = 3/group). Scale bar = 300 μm. Brain TH-ir neuron number was manually (b) and stereologically (c) counted, respectively, after LPS or vehicle treatment indicated in picture (a). ***p < 0.001 and NS compared with respective saline group. Two-way ANOVA followed by Bonferroni post hoc multiple comparison test

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Journal of Neuroinflammation

ISSN: 1742-2094