Fig. 1

Neutrophil-specific Cxcr2 knockout ameliorates EAE disease. a Schema for experimental design and time schedule. b Daily EAE disease scores of wild-type control and neutrophil-specific Cxcr2 knockout mice (Cxcr2 cKO), up to 40 days post-induction (dpi). Control EAE, n = 10; Cxcr2 cKO EAE, n = 10. c Serum CXCL1 levels in control non-induced mice (as indicated by 0 dpi) and EAE-induced mice at 9, 21, and 40 dpi. Note: error bar is present for control group (0 dpi). However, error bar is not visible due to small variation in CXCL1 amount in control groups. Significance was calculated by comparing CXCL1 levels at different time points with 0 dpi. n = 8. *p < 0.05, two-tailed unpaired Student’s t test