Activated STAT3 signaling pathway by ligature-induced periodontitis could contribute to neuroinflammation and cognitive impairment in rats

Hu, Yi; Zhang, Xu; Zhang, Jing; Xia, Xinyi; Li, Huxiao; Qiu, Che; Liao, Yue; Chen, Huiwen; He, Zhiyan; Song, Zhongchen; Zhou, Wei

doi:10.1186/s12974-021-02071-9

Journal of Neuroinflammation

Table 1 The sequences of genes and primer pairs

From: Activated STAT3 signaling pathway by ligature-induced periodontitis could contribute to neuroinflammation and cognitive impairment in rats

Target Gene
GAPDH	Forward:5’-ACAGTCCATGCCATCACTGCC-3’
GAPDH	Reverse:5’-GCCTGCTTCACCACCTTCTTG-3’
IL-1β	Forward:5’-AACCTGCTGGTGTGTGACGTTC-3’
IL-1β	Reverse:5’-CAGCACGAGGCTTTTTTGTTGT-3’
IL-6	Forward:5’-GCCCTTCAGGAACAGCTATGA-3’
IL-6	Reverse:5’-TGTCAACAACATCAGTCCCAAGA-3’
IL-8	Forward:5’-CATTAATATTTAACGATGTGGATGCG-3’
IL-8	Reverse:5’-GCCTACCATCTTTAAACTGCACAAT-3’
IL-21	Forward:5’-GCTCCACAAGATGTAAAGGG-3’
IL-21	Reverse:5’-GTGCCTCTGTTTATTTCCTG-3’
APP	Forward:5’-AGAGGTCTACCCTGAACTGC-3’
APP	Reverse:5’-ATCGCTTACAAACTCACCAACT-3’
APLP1	Forward:5’-TCAGGTCTGCTGATCATGGGAGC-3’
APLP1	Reverse:5’-TGGGTGGGGAAGAGGACTTTATTG-3’
APLP2	Forward:5’-CAGAGCGACAGACCCTCATTC-3’
APLP2	Reverse:5’-TCTACTCGGGCCAAATGGGT-3’
ADAM10	Forward:5’-GCCTATGTCTTCACGGACCG-3’
ADAM10	Reverse:5’-TGCCAGACCAAGAACACCATC-3’
ADAM17	Forward:5’-CAGGACGTAATTGAGCGGTTTT-3’
ADAM17	Reverse:5’-ACGATGTTGTCTGCCAGAAACTT-3’
BACE1	Forward:5’-CGGGAGTGGTATTATGAAGTG-3’
BACE1	Reverse:5’-AGGATGGTGATGCGGAAG-3’
PS1	Forward:5’-GAGGAAGACGAAGAGCTGACAT-3’
PS1	Reverse:5’-GAAGCTGACTGACTTGATGGTG-3’
PS2	Forward:5’-GAGCAGAGCCAAATCAAAGG-3’
PS2	Reverse:5’-GGGAGAAAGAACAGCTCGTG-3’
TLR2	Forward:5’-GTACGCAGTGAGTGGTGCAAGT-3’
TLR2	Reverse:5’-GGCCGCGTCATTGTTCTC-3’
TLR4	Forward:5’-AGCCATTGCTGCCAACATCA-3’
TLR4	Reverse:5’-GCCAGAGCGGCTACTCAGAAAC-3’
CD14	Forward:5’-CTCAACCTAGAGCCGTTTCT-3’
CD14	Reverse:5’-CAGGA TTGTCAGACAGGTCT-3’
NF-κB	Forward:5’-CAAGATCTGCCGAGTAAACC-3’
NF-κB	Reverse:5’-TCGGAACACAATGGCCACTT-3’
PPAR	Forward:5’-AAGAACCTGAGGAAGCCA-3’
PPAR	Reverse:5’-AGCCACAAAAAGGGAAATG-3’
SOD	Forward:5’-CACTCTAAGAAACATGGCG-3’
SOD	Reverse:5’-CTGAGAGTGAGATCACACG-3’
CAT	Forward:5’-ATGGCTTTTGACCCAAGCAA-3’
CAT	Reverse:5’-CGGCCCTGGAGCATCTTGT-3’
GPx5	Forward:5’-CACCCCTCAGAGACTGTGGT-3’
GPx5	Reverse:5’-TTGACAGTGCTGACAGGAGC-3’

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ISSN: 1742-2094

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