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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis

Fig. 2

Blimp1-deficient Tregs are unstable and convert into TH17-like cells in EAE mice. a Frequency of splenic (SP) and spinal cord (SC) FoxP3+ Tregs from mice at day 20 post-EAE induction, as in Fig. 1a. b Expression of each molecule in SP and SC FoxP3+ Tregs from mice in a. c Expression of CD73 and FR4 in FoxP3+ Tregs (top) and the ratios of non-anergic (CD73FR4) to anergic (CD73+FR4+) population (bottom). d Production of IL-17A and GM-CSF by FoxP3+ Tregs. e Frequency of GM-CSF+ and IL-17A+ FoxP3+ Tregs from mice in a. WT, FoxP3YFP-Cre; KO, Prdm1fl/flFoxP3YFP-Cre. Data represent one of at least three experiments (a, c, e n = 5/group). *P < 0.05, **P < 0.01, and ****P < 0.0001 (unpaired two-tailed Student’s t test). Bars, mean ± SEM

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