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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Fig. 8

Spleen size in CpG ODN-stimulated and in buffer-treated control animals. (a) Photograph taken 36 h after infection, i.e., 4.5 days after CpG ODN stimulation, shows the strong enlargement of the spleen. (b) The spleen was enlarged in wild-type, but not in TLR9−/− mice sacrificed after CpG ODN stimulation and infection. (c, d) Enlargement of the spleen was present in neutropenic and immunocompetent wild-type mice after CpG ODN stimulation and sacrificed after infection. The weight and age of the mice of the CpG ODN-stimulated and of the control group at the beginning of the experiment did not differ significantly indicating a similar size of the animals in the CpG ODN-stimulated and control group. When the spleen length was divided by the body weight of each mouse, the results of the statistical analysis remained unchanged being P values as follow (b), neutropenic wild-type mice: P < 0.0001; TLR-deficient mice: P = 0.45; (c): P = 0.001; (d): P = 0.007, Mann-Whitney U test). *** P ≤ 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094