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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

Fig. 5

Effects of knockout MC1R and Nurr1 on infarct area, body weight, and neurological function at 48 h post-HI. a, b The infarct area was significantly increased in both treatment groups with CRISPR compared to the HI + BMS-470539 group or HI + BMS-470539 + control CRISPR group. c Activation of MC1R with BMS-470539 significantly reduced body weight loss compared to the vehicle. However, both treatment groups with CRISPR interventions significantly reversed these effects compared to the HI + BMS-470539 group or HI + BMS-470539 + control CRISPR group. d The geotaxis test showed that the rat pups treated with BMS-470539 and either MC1R CRISPR or Nurr1 CRISPR had significantly impaired neurological function compared to the corresponding controls. Data was represented as mean ± SD. *p < 0.05 versus sham, #p < 0.05 versus HI + vehicle, @p < 0.05 HI + BMS-470539 or HI + BMS-470539 + control CRISPR. n = 6 per group

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Journal of Neuroinflammation

ISSN: 1742-2094