Fig. 1

Blocking of GPIb delays ischemic brain damage. Representative images of coronal sections stained with a TTC, b Map2a/b 2, 3 and 4 h after MCAO or after 2 h of MCAO with additional 6 h of reperfusion in mice treated with rat IgG Fab (Ctrl Fab) or p0p/B Fab (a-GPIb Fab) immediately or 1 h after MCA occlusion. Infarcted areas are shown in white. Planimetric analyses were used to quantify the infarct volumes. Results are presented as box plots (n = 4–9). *P< 0.05, **P< 0.01, ***P< 0.001 between the indicated groups, 2-tailed Student t test or, in the case of nonparametric functional outcome, the Wilcoxon–Mann–Whitney U-test was applied. b.d., beyond detection level