ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex

Table 1 Properties of Ca²⁺ transients evoked in human microglial cells under different experimental conditions

Stimulus	Resp. cells (%)	Basal (R)	Peak (R)	ΔR	T_0-100 (s)	T_100-50 (s) [n]
ATP	100 (62/62)	0.22±0.01	0.36±0.02	0.142±0.002	114±8	419±24 [27]
ATP (LPS)	97.6 (41/42)	0.219±0.007	0.35±0.02	0.13±0.02	67±6	353±24 [28]
ATP Ca²⁺-free	65.2 (15/23)	0.177±0.007	0.191±0.008	0.014±0.004	336±29	Nd [15]
GSK 1702934A	61.6 (74/120)	0.42±0.01	0.48±0.02	0.059±0.004	42±3	441±19 [29]
Thapsigargin	28.4 (19/67)	0.33±0.03	0.37±0.04	0.039±0.004	47±6	307±34 [5]

Amplitude and kinetic parameters of evoked Ca²⁺ transients were measured on a subset [n] of total responsive cells, in which it was possible to resolve the peak and the recovery of the Ca²⁺ signal. Data were obtained from 3, 2, 3, 2, and 2 different patients for ATP, ATP in LPS-treated cells, ATP in Ca²⁺-free, GSK 1702934A, and thapsigargin, respectively

ISSN: 1742-2094