|
Stimulus
|
Resp. cells (%)
|
Basal (R)
|
Peak (R)
|
ΔR
|
T0-100 (s)
|
T100-50 (s) [n]
|
|---|
|
ATP
|
100 (62/62)
|
0.22±0.01
|
0.36±0.02
|
0.142±0.002
|
114±8
|
419±24 [27]
|
|
ATP (LPS)
|
97.6 (41/42)
|
0.219±0.007
|
0.35±0.02
|
0.13±0.02
|
67±6
|
353±24 [28]
|
|
ATP Ca2+-free
|
65.2 (15/23)
|
0.177±0.007
|
0.191±0.008
|
0.014±0.004
|
336±29
|
Nd [15]
|
|
GSK 1702934A
|
61.6 (74/120)
|
0.42±0.01
|
0.48±0.02
|
0.059±0.004
|
42±3
|
441±19 [29]
|
|
Thapsigargin
|
28.4 (19/67)
|
0.33±0.03
|
0.37±0.04
|
0.039±0.004
|
47±6
|
307±34 [5]
|
- Amplitude and kinetic parameters of evoked Ca2+ transients were measured on a subset [n] of total responsive cells, in which it was possible to resolve the peak and the recovery of the Ca2+ signal. Data were obtained from 3, 2, 3, 2, and 2 different patients for ATP, ATP in LPS-treated cells, ATP in Ca2+-free, GSK 1702934A, and thapsigargin, respectively
