Fig. 2

AβOs trigger abnormal mitochondrial dynamic proteins changes in the brains of cynomolgus macaques. a Representative images of MFN-1, MFN-2, OPA-1, and Drp1 immunolabeling in the frontal cortex of sham-operated and AβO-injected macaques. Nuclear staining (DAPI) is shown in blue. Scale bar: 20 μM. b Quantification of MFN-1-, MFN-2-, OPA-1-, and Drp1-positive cells. Data are expressed as means ± SEM (n = 3 sham; n = 4 AβOs). **p < 0.01, *p < 0.05, Student’s unpaired t test