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Table 1 CIDP variants and their main features

From: The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

CIDP variant Main features
Typical CIDP • Symmetric, sensory and motor symptomology following a chronic course
• A subpopulation has an acute onset
Sensory predominant CIDP • Involves sensory over motor symptoms following a chronic course
CISP • Younger age of onset
Seropositive CIDP • Presence of antibodies against NF155, tremors, sensory and cerebellar ataxia, weakness
NF155 • Younger age of onset
NF186 • Presence of antibodies against NF186, subacute onset, sensory ataxia
CNTN1 • Presence of antibodies against NF186, subacute onset, sensory ataxia
• Older age of onset
CASPR • Presence of antibodies against Caspr, subacute and severe, motor dominant, painful
Lewis-Sumner Syndrome (aka multifocal-acquired demyelinating sensory and motor polyneuropathy) • Asymmetric sensory and motor symptoms following a chronic course
Motor predominant CIDP • Involves motor over sensory symptoms following a chronic course
• More common in juveniles
Distal-acquired demyelinating symmetric neuropathy (DADS) • Symptoms appear distally and are predominantly sensory over motor following a chronic course
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