Table 1 CIDP variants and their main features

Typical CIDP

• Symmetric, sensory and motor symptomology following a chronic course

• A subpopulation has an acute onset

Sensory predominant CIDP

• Involves sensory over motor symptoms following a chronic course

• CISP

• Younger age of onset

Seropositive CIDP

• Presence of antibodies against NF155, tremors, sensory and cerebellar ataxia, weakness

• NF155

• Younger age of onset

• NF186

• Presence of antibodies against NF186, subacute onset, sensory ataxia

• CNTN1

• Presence of antibodies against NF186, subacute onset, sensory ataxia

• Older age of onset

• CASPR

• Presence of antibodies against Caspr, subacute and severe, motor dominant, painful

Lewis-Sumner Syndrome (aka multifocal-acquired demyelinating sensory and motor polyneuropathy)

• Asymmetric sensory and motor symptoms following a chronic course

Motor predominant CIDP

• Involves motor over sensory symptoms following a chronic course

• More common in juveniles

Distal-acquired demyelinating symmetric neuropathy (DADS)

• Symptoms appear distally and are predominantly sensory over motor following a chronic course