Fig. 3
From: The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve
Jagged-1/Notch signaling and regulation in the context of BACE1 activity. A cell that is sending (top) a Notch signal to a receiving cell (Bottom) via notch ligand Jag1. (1) Notch/Jag1 binding causes a conformational change in Notch1 which results in subsequent cleavages, resulting in the release of the intracellular domain of Notch (NCID) to relocate to the nucleus and activate downstream signaling. (2) Notch signaling can be regulated by binding Jag1 on the surface of the receiving cell. (3) BACE1 can regulate Notch1 signaling via the cleavage of Jag1. This cleavage can have different effects depending on whether it is taking place on a receiving cell or sending cell. In the sending cell, BACE1 activity results in reduced Jag1 available for signaling. In the receiving cell BACE1 activity results in increased Notch1 signaling by reducing the amount of cis-regulating Jag1