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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

Fig. 4

TSPO ligand reduces hippocampal neuroinflammation in TauTg mice. a Representative images of TSPO (left panel), IBA-1 (middle panel), and C1q (right panel) immunoreactivity in the hippocampus of 9-month-old nonTg, and TauTg mice treated with either vehicle or Ro5. Inset shows digitally magnified view of image. b-d Quantification of immunoreactivity of the inflammatory markers, TSPO (b), IBA-1 (c), and C1q (d) in the hippocampus and cerebral cortices of nonTg (N = 12) and TauTg mice treated with either Ro5 (N = 7) or vehicle (N = 6). Individual data points plotted for each group and the group mean indicated (black bar). PERMANOVA, *pperm < 0.03. e Representative gating (left) and flow cytometry histogram of C1q levels (right) in unstimulated BV2 cells (black) or following stimulation with LPS after pretreatment with either vehicle (blue) or Ro5 (red). MFI, mean fluorescent intensity. SSC, side scatter. FSC, forward scatter. f Quantification of C1q binding in BV2 cells (n=3-4/group/experiment, single experiment shown, experiment replicated 3 times). One-way ANOVA. **p = 0.003

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