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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Fig. 4

Repeated INCB3344 treatment inhibits the expression of various pro-nociceptive peptides. mRNAs were extracted from ipsilateral rat DRG L4-L6 on day 10 post-CFA, after three daily i.t. injection of vehicle (DMSO 6%) or 45 μg/kg INCB3344. Relative expression of each gene of interest was obtained by qPCR using the standard curve method. Results represent the fold increase in mRNA expression induced by CFA with or without treatment with INCB3344. Data are expressed as mean ± SEM (n = 8 animals for each group). ***P < 0.001 when comparing the Sham group with the CFA + vehicle group. #P<0.05 when comparing CFA + INCB3344 to CFA + vehicle; one-way ANOVA followed by a Bonferroni’s post-test

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