The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

Table 1 Expression of NLRP3 inflammasome components under different pain conditions

Tissue type	Pain condition	Marker	Cell type	Colocalized with	References
DRG	Bortezomib-induced neuropathic pain	Neun	Neuron	NLRP3	[21]
		IB4	Non-peptidergic neuron	NLRP3
		NF200	Large diameter neuron	NLRP3
		ED1	Macrophage	NLRP3
	Paclitaxel-induced neuropathic pain	CD68	Macrophage	NLRP3	[20]
Sciatic nerve	Paclitaxel-induced neuropathic pain	CD68	Macrophage	NLRP3	[20]
Skin	CFA-induced inflammatory pain	CD68	Macrophage	NLRP3	[40]
		Cytokeratin	Keratinocyte	NLRP3
		TCRα/β	T cell	NLRP3
Muscle	Muscle pain	CD68	Macrophage	NLRP3	[41]
Spinal cord	CCI	Neun	Neuron	NLRP3	[42]
		GFAP	Astrocyte	NLRP3
		CD11b	Microglia	NLRP3
	Bone cancer pain	Neun	Neuron	NLRP3 ASC Caspase-1	[15]
		GFAP	Astrocyte	NLRP3 Caspase-1
		Iba1	Microglia	NLRP3
	CPIP	P2Y12	Microglia	IL-1β	[8]
	Morphine-induced hyperalgesia	Iba1	Microglia	NLRP3	[22]
TNC	Nitroglycerin-induced migraine	Iba1	Microglia	NLRP3 IL-1β	[34]
DRN	Morphine- or fentanyl-induced hyperalgesia	Neun	Neuron	NLRP3	[24]
DRN	Morphine- or fentanyl-induced hyperalgesia	GFAP	Astrocyte	NLRP3	[24]
PFC	Morphine analgesic tolerance	CD68	Microglia	ASC	[23]

ISSN: 1742-2094