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Table 1 Expression of NLRP3 inflammasome components under different pain conditions

From: The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

Tissue type Pain condition Marker Cell type Colocalized with References
DRG Bortezomib-induced neuropathic pain Neun Neuron NLRP3 [21]
IB4 Non-peptidergic neuron NLRP3
NF200 Large diameter neuron NLRP3
ED1 Macrophage NLRP3
Paclitaxel-induced neuropathic pain CD68 Macrophage NLRP3 [20]
Sciatic nerve Paclitaxel-induced neuropathic pain CD68 Macrophage NLRP3 [20]
Skin CFA-induced inflammatory pain CD68 Macrophage NLRP3 [40]
Cytokeratin Keratinocyte NLRP3
TCRα/β T cell NLRP3
Muscle Muscle pain CD68 Macrophage NLRP3 [41]
Spinal cord CCI Neun Neuron NLRP3 [42]
GFAP Astrocyte NLRP3
CD11b Microglia NLRP3
Bone cancer pain Neun Neuron NLRP3
ASC
Caspase-1
[15]
GFAP Astrocyte NLRP3
Caspase-1
Iba1 Microglia NLRP3
CPIP P2Y12 Microglia IL-1β [8]
Morphine-induced hyperalgesia Iba1 Microglia NLRP3 [22]
TNC Nitroglycerin-induced migraine Iba1 Microglia NLRP3
IL-1β
[34]
DRN Morphine- or fentanyl-induced hyperalgesia Neun Neuron NLRP3 [24]
GFAP Astrocyte NLRP3
PFC Morphine analgesic tolerance CD68 Microglia ASC [23]