Fig. 2

Increased myelon infiltration in the cerebellum of EAE-induced GF-IL23 mice. HE-staining of the myelon (transverse sections) at different time points (d0, d15, d22, d33, d60). GF-IL23 naïve mice show no infiltration (a WT control E). b–d I GF-IL23 mice show enhanced infiltration over the time, especially at d22, d33 compared to WT mice (f, g, h, j). Arrows point to infiltrates. Scale bar: 100 μm. The images are representative of those from at least different 8 transgenic/WT mice d0, d15, d22, d33, and 8 transgenic, 6 WT mice d60. k Demyelinated area relative to the white matter area was quantified in cross-sections of the spinal cord from GF-IL23 and WT mice (n = 4–5 for each group) with *p < 0.05 and **p< 0.01 and showed a significant enhanced demyelination in GF-IL23 mice