Fig. 4

Infiltration of the ventricle, meninges, and parenchyma of the forebrain and brain stem in GF-IL23 mice. a Fraction of GF-IL23 and WT EAE mice with cellular infiltrates in ventricles, meninges, parenchyma, or brain stem. Naïve mice did not show these infiltrates. Transgenic mice show infiltrates from day 15 in these locations, whereas only sporadic infiltrates were found in WT mice. b–i Exemplary histology findings at d33. b, d, f, h Beside the cerebellum, infiltrates (arrow heads) in other locations such as ventricle, meninges, and parenchyma of the forebrain and brain stem were found in GF-IL23 mice. WT mice (c, e, g, i) display no infiltrates in these locations. Scale bar: 100 μm. The images are representative of those from at least 8 different transgenic/WT mice d33