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Table 1 Clinical features of the EAE in GF-IL23 and WT mice

From: Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model

 

Myelitis

Ataxia

GF-IL23

WT

GF-IL23

WT

Incidence

12/12

8/9

7/9

0/9

Disease (days) onset

11.5 ± 1.5*

15.5 ± 7.5

36.0 ± 14.5***

-

Time (days) to maximum

21.5 ± 6.0

23.5 ± 14.0

44.5 ± 10.0***

-

Maximum score

3.3 ± 1.0

2.5 ± 0.4

2.9 ± 1.8**

-

Outcome (d60)

3.3 ± 1.0***

1.1 ± 0.3

2.9 ± 1.7**

-

  1. *p < 0.05, **p < 0.01, ***p < 0.001
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Journal of Neuroinflammation

ISSN: 1742-2094