Fig. 1

Interruption of white matter linear integrity by system LPS, obviously reversed by minocycline. a FA and MD values were measured and analyzed on the regions of interest in the rostral (red frame) and middle (green frame) parts of the CC body. b The FA values, namely linear movements of water molecules paralleling with the axons, were significantly distorted by system LPS (N = 8 in both saline and LPS groups; p < 0.05, shown as *), while minocycline reversed this distortion to an approximately significant level (N = 8 in both LPS and LPS + minocycline groups; p = 0.0657). c The MD values, namely water diffusion with angles to the axons, were enhanced to an almost significant level comparing to the saline group (p = 0.0570); however, co-delivery of minocycline seemed to invert this effect