Fig. 1
From: STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis
Steap4 promotes actively-induced EAE. a Microarray analysis of STEAP4 expression in spinal cords from indicated mice that received MOG35–55-reactive Th17 cells and at the peak of Th17-driven EAE, relative to the naïve control mice. Data are re-plotted from GSE97035. b Mean clinical score of EAE in STEAP4+/− and Steap4+/− mice induced by active immunization with MOG35–55 (p < 0.05, two-way ANOVA). c H&E, anti-CD4, and myelin basic protein (MBP) staining of lumber spinal cords 20 days after immunization (scale bar, 200 μm). d Absolute cell numbers of infiltrated immune cells in the brains of STEAP4+/− and STEAP4+/− mice 20 days after immunization. Data are representative of three independent experiments. n = 5/group in each experiment. Error bars, SEM; *p < 0.05, ***p < 0.001