Skip to main content
Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia

Fig. 10

Schematic showing BDNF/TrkB.T1 contributes to RTX-induced postherpetic neuralgia through regulating ASIC3 signaling. RTX injection increased the synthesis and secretion of BDNF from activated satellite glial cells and neurons in DRGs. Then, BDNF activated ASIC3 signaling through increasing TrkB.T1 receptors in neurons, which led to elevated expression of c-FOS, TRAF6, and nNOS, as well as enhanced transcription of IL-6, IL-1β, TNF-α. Finally, the inflammatory response and NO production induced neuronal excitability and promoted the development and maintenance of pain

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094