Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?

Table 2 Comparison of OCT and VEP measures as well as visual acuity between MOGAD-ON and MOGAD-NON eyes in pediatric and adult MOGAD patients

Parameter	Pediatric patients		Adult patients		Pediatric patients	Adult patients	MOGAD-ON eyes	MOGAD-NON eyes
Parameter	MOGAD-ON eyes (30 eyes, mean± SD)	MOGAD-NON eyes (10 eyes, mean± SD)	MOGAD-ON eyes (42 eyes, mean± SD)	MOGAD-NON eyes (36 eyes, mean± SD)	MOGAD-ON vs. MOGAD-NON eyes, p	MOGAD-ON vs. MOGAD-NON eyes, p	Pediatric vs. adult patients, p	Pediatric vs. adult patients, p
pRNFL G	63.12 ± 18.74	90.30 ± 13.40	64.26 ± 22.85	96.64 ± 20.67	< 0.001	0.001	0.997	0.292
TMV	2.19 ± 0.11	2.30 ± 0.13	2.22 ± 0.12	2.31 ± 0.11	0.021	0.048	0.484	0.718
mRNFL	0.12 ± 0.02	0.14 ± 0.01	0.13 ± 0.02	0.14 ± 0.03	< 0.001	0.537	0.012	0.278
mGCIPL	0.42 ± 0.09	0.57 ± 0.08	0.44 ± 0.13	0.57 ± 0.08	< 0.001	0.012	0.555	0.853
mINL	0.28 ± 0.03	0.26 ± 0.02	0.29 ± 0.04	0.26 ± 0.02	0.001	0.017	0.793	0.994
mOPONL	0.77 ± 0.07	0.74 ± 0.08	0.77 ± 0.05	0.75 ± 0.05	0.307	0.949	0.779	0.589
VEP P100 latency	117.86 ± 10.67	112.44 ± 9.59	117.99 ± 14.51	118.15 ± 9.84	0.324	0.790	0.946	0.115
VEP amplitude	10.57 ± 6.12	8.52 ± 4.47	5.76 ± 2.79	7.61 ± 5.21	0.235	0.049	–	–
HC VA	51.36 ± 9.33	55.60 ± 8.88	34.97 ± 20.57	52.03 ± 8.67	0.245	0.002	< 0.0001	0.325
2.5% LC VA	22.83 ± 14.62	25.60 ± 13.94	13.54 ± 16.44	29.52 ± 13.89	0.963	0.017	0.028	0.451

GEE analysis: p value: significant results p < 0.05 are indicated in bold
Abbreviations: MOGAD-ON eyes with a history of ON, MOGAD-NON eyes without a history of ON, pRNFL peripapillary retinal nerve fiber layer (G global), TMV total macular volume, mRNFL macular RNFL, mGCIPL macular ganglion cell and inner plexiform layer, mINL macular inner nuclear layer, mOPONL macular outer plexiform and outer nuclear layer, HC high-contrast, LC low-contrast, VA visual acuity, pRNFL thickness in μm, macular volumes in mm³, VEP P100 latency in ms, VEP amplitude in uV, VA number of correctly stated letters

ISSN: 1742-2094