Fig. 7
From: Capsazepine decreases corneal pain syndrome in severe dry eye disease
Ex vivo evaluation of spontaneous and evoked activity of the ciliary nerve in DED animals treated with 10μM capsazepine or vehicle. Histograms show the mean value of the frequency activity of the ciliary nerve at (a) 32°C and pH 7.4, (b) 20°C, (c) 40°C, (d) pH 6, and (e) pH 5 for DED animals treated with 10 μM capsazepine or vehicle. Total number of mice = 20. Number of mice included in the analysis = 20. DED animals treated with vehicle and 10 μM capsazepine: n = 10. All experiments were conducted on d21. *P < 0.05, **P < 0.01 relative to DED animals treated with vehicle. Results are expressed as the mean ± SEM. For statistical analysis, the Kolmogorov–Smirnov test was performed followed by a parametric t-test using GraphPad Prism version 7.00 (GraphPad Software, La Jolla, CA, USA)