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Table 1 Criteria definition in the evaluation of histomorphological scores for murine intestinal inflammation

From: High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors

Features

Scoring criteria

Score

Extent of mucosal villi damage

No damage

1

Damage in <1/3 of villi

2

Damage between 1/3 and 2/3 of villi

3

Damage >2/3 of villi

4

Mucosal damage degree

No damage

1

Swelling and loss of lamina propria matrix

2

Loss of epithelium surface from villus tip to its base

3

Loss of villi

4

Infiltration of Inflammatory cells degree

Normal

1

Mild

2

Moderate

3

Dense

4

Goblet cells depletion

Absence

1

Presence

2

Crypts absence

Absence

1

Presence

2