Fig. 3

Upregulation of inflammatory cytokines in the temporal cortex of Aβ+ individuals. a–s Cytokine expression assessed by multispot immunoassays revealed increased levels (dotted line) of a IL-1β, two-tailed Student t test; t (24) = 2.403, p = 0.024; Aβ−, n = 14; Aβ+, n = 12; b IL-6, two-tailed Student t test; t (24) = 2.56, p = 0.017; Aβ−, n = 14; Aβ+, n = 12 and D eotaxin-3, two-tailed Student t test; t (22) = 3.594, p = 0.001; Aβ−, n = 14; Aβ+, n = 10, in the temporal cortex of non-demented individuals with Aβ deposition as compared with individuals without Aβ deposition in this brain region. c, e–s Expression of other cytokines (MCP-1, IL-1α, IL-4, IL-7, IL-8, IL-10, IL-12p40, IL-13, IL-15, IL-16, IFNγ, IP-10, MDC, MIP-1β, TARC, and TNFα) did not differ between Aβ− and Aβ+ individuals. Data are displayed in boxplots where the median is represented by the horizontal line, and the whiskers represent the 25th and 75th percentiles. ^*p < 0.05